LATEST NEWS

Insights into CYP17A1 activities and binding of anti-prostate cancer drug abiraterone

IMechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

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Book: Role of Protein-Protein Interactions in Metabolism: Genetics,Structure, Function. 2018

Edited by: Amit V. Pandey, Colin J. Henderson, Yuji Ishii, Michel Kranendonk, Wayne L. Backes, Ulrich M. Zanger

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Research from Pandeylab in News Media

 

Recent work from lab 

At Urotoday

@ mta-portal.de

@ innovations-report.de

@ medicalxpress.com

 

 

 

 

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Recent and upcoming presentations from Lab

POR @ Adrenal 2018, June 26, Munich, Germany

Genotype Phenotype coorelations of POR mutations at the 18th Adrenal Cortex Conference at Munich, Germany

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Steroid Metabolism @ University of saarland, Germany, April 2018

Lecture at Steroid seminar, Saarland University, Germany

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ESPE Annual Meeting, Athens, Greece, September 2018

P450 Oxidoreductase and human disease

 

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7th I-DSD Meeting, Sao Paulo, Brazil July 2019

Bioinformatics methods for analysis of DSD genes

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Presentations:

Experimental Biology 2017 / ASPET Meeting, Chicago

Efects of common polymorphic variants of POR on drug and steroid metabolism

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10th International Pediatric Endocrinology Meeting, September 2017, Washington DC

Growth hormone mutation analysis by structure function studies.

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10th International Pediatric Endocrinology Meeting, September 2017, Washington DC

Effect on POR mutations on non-clinical populations on drug and steroid metabolism

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ENDO2017, Orlando, Florida, April 2017

Abiraterone side effects on CYP21A2 activities.

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57th ESPE Meeting Athens, 2018

Changes in CYP19A1 and CYP3A4 activities due to population genetic variations in human P450 Oxidoreductase.

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57th ESPE Meeting, Athens, Greece, 2018

Computational analysis of thyroid hormone receptor for the rational design biosensor for the detection of thyroid hormone disrupting chemicals.

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Miletta MC, Eblé A, Janner M, Parween S, Pandey AV, Flück CE, Mullis PE. IGHD II: A Novel GH-1 Gene Mutation (GH-L76P) Severely Affects GH Folding, Stability, and Secretion. J Clin Endocrinol Metab. 2015 Dec;100(12):E1575-83.

On Cover Page December 2015

Pandey, AV. Bioinformatics tools and databases for the study of human growth hormone. Endocrine Dev.  23: 71-85 (2012). 

On the cover: GHR-GH complex

Fluck CE & Pandey, AV. Clinical and biochemical consequences of P450 oxidoreductase deficiency. Endocr. Dev 20:63-79 (2011)

 

On cover P450, b5

Fluck CE, Pandey AV, Huang N, Agrawal V, Miller WL. P450 oxidoreductase deficiency - a new form of congenital adrenal hyperplacia. Endocr Dev, 13: 67-81 (2008).

On the cover: POR

Pandey, AV and Miller, WL. Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. J. Biol Chem. 280: 13265-13271 (2005)

 

April 08, 2005 Cover Page.

Pandey, AV and Chauhan, VS Heme polymerisation by malarial parasite : A potential target for antimalarial drug development. Current Sc. 75:911-918 (1998).

 

Role of Human P450 Oxidoreductase in steroid metabolism
University of Bern
DKF University of Bern
Amit Pandey @ Research Gate
Amit Pandey @ Google Scholar
Amit Pandey @ Frontiers in Pharmacology

Contact

PD Dr. Amit V Pandey
Pediatric Endocrinology, Diabetology and Metabolism,

KIKL C837, Inselspital

University Children's Hospital Bern,

Freiburgstrasse 15, 3010 Bern

Switzerland


Tel: +41 31 632 9637 (Office)

        +41 31 632 9527 (Lab)

E-mail: amit@pandeylab.org

 

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